Did you know that paliperidone prolonged-release tablets should be taken consistently either with food or without, not alternating between fasting and fed states.

This seems to have been recommended because clinical studies assessing safety and efficacy of paliperidone did not take fasting or fed states into account, whereas pharmacokinetic studies have shown an increase in C_max of 60% and AUC of 54% when given with a high calorie meal.